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. 2022 Apr 29;23(9):4948. doi: 10.3390/ijms23094948

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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FTO affects m⁶A modification and the expression level of the MNT mRNA. (A) RT-qPCR results revealed the relative expression of seven potential target genes in the control and Cd groups. (B) Determination of FTO expression level after transfection with pcDNA3.1-FTO or pcDNA3.1-Vector. (C) RT-qPCR results revealed the mRNA expression of target genes after FTO overexpression. (D) Distribution of m⁶A peaks across MNT transcriptome. (E) Determination of m⁶A modification level of MNT mRNA after Cd treatment and FTO overexpression using MeRIP-RT-qPCR. (F) Western blotting results showed MNT protein expression after Cd treatment and FTO overexpression. (G) Western blotting results showed MNT protein expression after Cd and siYTHDF2 treatments. * p < 0.05; ** p < 0.01.