Table 6.
Overall survival (OS) in HPV-/HPV+ patients: univariate and multivariate analysis.
| Variable | OS HPV- | OS HPV+ | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariate Analysis | Univariate Analysis | Multivariate Analysis | |||||||
| HR (95%CI) |
p-Value | HR (95%CI) |
p-Value | HR (95%CI) |
p-value | HR (95%CI) |
p-Value | |||
| CRP > 3.50 vs. < 3.50 |
62 | 2.08 (0.90–4.82) |
0.088 | 3.45 1.37–8.68 |
0.008 | 58 | 2.23 (0.70–7.13) |
0.176 | 2.92 0.90–9.46 |
0.075 |
| Albumin (g/L) > 40.0 vs. < 40.0 |
62 | 1.14 (0.50–2.62) |
0.755 | 57 | 3.26 (0.71–14.89) |
0.127 | 4.21 0.89–19.86 |
0.070 | ||
| Prealbumin (g/L) > 0.28 vs. < 0.28 |
46 | 0.44 (0.12–1.58) |
0.208 | 44 | 2.37 (0.59–9.54) |
0.223 | ||||
| Hb 0 (g/dL) > 13.5 vs. < 13.5 |
68 | 0.69 (0.32–1.49) |
0.345 | 59 | 1.31 (0.39–4.37) |
0.659 | ||||
| LC 0 (/mm3) > 1.28 vs. < 1.28 |
68 | 0.63 (0.26–1.50) |
0.299 | 59 | 0.63 (0.17–2.35) |
0.496 | ||||
| PNI > 39.01 vs. < 39.01 | 62 | 1.04 (0.42–2.53) |
0.935 | 57 | 1.56 (0.34–7.16) |
0.569 | ||||
| Age > 60 vs. ≤ 60 | 68 | 0.788 (0.36–1.71) |
0.546 | 59 | 0.85 (0.27–2.63) |
0.772 | ||||
| Gender F vs. M | 0.49 (0.18–1.31) |
0.157 | 0.12 0.02–0.58 |
0.009 | 59 | 0.58 (0.16–2.15) |
0.414 | |||
| General location tonsils vs. others |
68 | 1.57 (0.68–3.63) |
0.289 | |||||||
| Tumor depth (T) T3–4 vs. T1–2 |
67 | 0.95 (0.44–2.06) |
0.899 | 59 | 1.79 (0.48–6.62) |
0.385 | ||||
| Lymph node metastasis N2–3 vs. N0–1 | 68 | 1.80 (0.83–3.93) |
0.139 | 58 | 1.15 (0.31–4.26) |
0.832 | ||||
| Radiotherapy vs. chemoradiotherapy |
68 | 0.93 (0.42–2.06) |
0.858 | 59 | 0.60 (0.08–4.64) |
0.623 | ||||
| BMI 0 > 24.53 vs. < 24.53 |
68 | 0.39 (0.17–0.87) |
0.022 | 59 | 0.57 (0.15–2.12) |
0.400 | ||||
| NRS 2002 > 1 vs. ≤ 1 |
4.03 (1.56–10.37) |
0.004 | 3.83 1.22–12.01 |
0.021 | 58 | 0.00 | 1.00 | |||
| Smoking Yes vs. no |
68 | 1.18 (0.49–2.84) |
0.706 | 59 | 0.63 (0.17–2.32) |
0.483 | ||||
| Alcohol abuse Yes vs. no |
68 | 4.17 (1.20–14.47) |
0.025 | 6.39 1.40–29.14 |
0.017 | |||||
0, before treatment; Hb, hemoglobin level; TLC, lymphocyte count.