Table 7.
Disease-free survival (DFS) in HPV-/HPV+ patients: univariate and multivariate analysis.
| Variable | DFS HPV- | DFS HPV+ | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariate Analysis | Univariate Analysis | Multivariate Analysis | |||||||
| HR (95%CI) |
p-Value | HR (95%CI) |
p-Value | HR (95%CI) |
p-Value | HR (95%CI) |
p-Value | |||
| CRP >3.50 vs. <3.50 |
62 | 2.78 1.13–6.82 |
0.026 | 2.90 1.08–7.76 |
0.034 | 58 | 4.95 1.18–20.76 |
0.029 | ||
| Albumin (g/L) >40.0 vs. <40.0 |
62 | 0.902 0.39–2.09 |
0.810 | 57 | 0.96 0.23–4.05 |
0.957 | ||||
| Prealbumin (g/L) >0.28 vs. <0.28 |
46 | 0.50 0.14–1.79 |
0.288 | 44 | 1.01 0.25–4.02 |
0.993 | ||||
| Hb 0 (g/dL) >13.5 vs. <13.5 |
68 |
0.38
(0.17–0.87) |
0.021 | 0.34 0.13–0.90 |
0.029 | 59 | 1.15 (0.27–4.82) |
0.848 | ||
| TLC 0 (/mm3) >1.28 vs. <1.28 |
68 | 0.61 (0.25–1.47) |
0.271 | 59 |
0.19
(0.05–0.77) |
0.020 |
0.20
(0.05–0.82) |
0.025 | ||
| PNI > 39.01 vs. < 39.01 | 62 | 0.55 0.23–1.28 |
0.163 | 57 | 0.45 0.11–1.89 |
0.276 | ||||
| Age > 60 vs. ≤ 60 | 68 | 0.75 0.34–1.65 |
0.474 | 59 | 0.88 0.22–3.53 |
0.859 | ||||
| Gender F vs. M | 68 | 0.99 0.41–2.39 |
0.984 | 59 |
0.95
0.22–3.96 |
0.941 | ||||
| General location tonsils vs. others |
68 |
1.35
0.58–3.15 |
0.482 | 59 | 1.00 | |||||
| Tumor depth (T) T3–4 vs. T1–2 |
67 | 1.20 0.54–2.64 |
0.655 | 59 |
2.02
0.41–10.00 |
0.390 | ||||
| Lymph node metastasisN2–3 vs. N0–1 | 68 |
3.55
(1.51–8.34) |
0.004 |
4.26
(1.59–11.43) |
0.004 | 58 | 2.86 (0.35–23.24) |
0.326 | ||
| Radiotherapy vs. chemoradiotherapy |
68 | 0.71 (0.31–1.64) |
0.422 | 0.00 | 1.00 | |||||
| BMI 0 >24.53 vs. <24.53 |
68 | 0.41 0.18–0.91 |
0.028 | 59 |
0.377
0.09–1.58 |
0.182 | ||||
| NRS 2002 >1 vs. ≤1 |
68 |
4.46
1.74–11.45 |
0.002 |
5.89
1.79–19.37 |
0.003 | 58 | 0.00 | 1.00 | ||
| Smoking Yes vs. no |
68 | 0.88 0.39–1.99 |
0.760 | 59 | 1.20 0.29–5.03 |
0.801 | ||||
| Alcohol abuse Yes vs. no |
68 | 2.92 0.68–12.59 |
0.150 | 8.01 1.41–45.39 |
0.019 | 59 | 1.00 | |||
0, before treatment; Hb, hemoglobin level; TLC, lymphocyte count.