Table 2.
Response by treatment arm
| HU (n = 86), % | PEG (n = 82), % | Difference in proportions for combined ET/PV, 95% CI (PEG – HU) | Rate ratio (95% CI) | |
|---|---|---|---|---|
| 12 mo | ||||
| Complete response | 32 (37) | 29 (35) | −2% | 0.95 |
| ET | 19 (45) | 17 (44) | (−16 to 13) | (0.64, 1.42) |
| PV | 13 (30) | 12 (28) | ||
| Overall response | 60 (70) | 64 (78) | 8% | 1.12 |
| ET | 30 (71) | 27 (69) | (−5 to 21) | (0.93, 1.34) |
| PV | 30 (68) | 37 (86) | ||
| 24 mo | (n = 54)* | (n = 52)* | ||
| Complete response | 11 (20) | 15 (29) | 9% | 1.42 |
| ET | 6 (25) | 9 (38) | (−9 to 26) | (0.72, 2.79) |
| PV | 5 (17) | 7 (25) | ||
| Overall response | 22 (41) | 31 (60) | 19% | 1.46 |
| ET | 8 (33) | 14 (58) | (1 to 37) | (1.00, 2.16) |
| PV | 14 (47) | 17 (61) | ||
| 36 mo | (n = 30)† | (n = 27)† | ||
| Complete response | 5 (17) | 9 (33) | 17% | 2.0 |
| ET | 2 (17) | 4 (40) | (−8 to 40) | (0.76, 5.23) |
| PV | 3 (17) | 5 (29) | ||
| Overall response | 14 (47) | 16 (59) | 13% | 1.27 |
| ET | 4 (33) | 6 (60) | (−15 to 38) | (0.77, 2.08) |
| PV | 10 (56) | 10 (59) |
Overall response rate = complete + partial response.
*
n = 106 patients (HU: 54, PEG: 52) who had the opportunity to receive treatment of 24 mo.
†
n = 57 patients (HU: 30, PEG: 27) who had the opportunity to receive treatment of 36 mo.