Table 4.
Author | Year | Country | Ethnicity | Case/Control, N | Case T Allele Freq | Control T Allele Freq | OR, 95% CI, p Value * | Population T Allele Frequency gnomAD |
---|---|---|---|---|---|---|---|---|
Hofmann S et al. [3] | 2008 | Germany | Caucasian | 1636/1811 | 0.33 | 0.41 | 0.70, 0.63–0.77, 1 × 10−12 | European: 0.42 |
Li et al. [4] | 2010 | Germany | Caucasian | 349/313 | 0.35 | 0.45 | 0.65, 0.52–0.81, 1 × 10−4 | European: 0.42 |
Mrazek et al. [5] | 2011 | Czech | Caucasian | 245/254 | 0.35 | 0.42 | 0.77, 0.59–0.99, 0.04 | European: 0.42 |
Levin et al. [6] # | 2013 | USA | European American | 446/350 | 0.36 | 0.42 | 0.76, 0.62–0.93, 0.008 | European: 0.42 |
African American | 1232/893 | 0.15 | 0.18 | 0.83, 0.70–0.97, 0.02 | African/African American: 0.20 | |||
Morais et al. [7] | 2013 | Portugal | Caucasian | 208/197 | 0.33 | 0.45 | 0.61, 0.46–0.81, 6 × 10−4 | European: 0.42 |
Feng et al. [8] | 2014 | China | Chinese-Han | 412/418 | 0.29 | 0.40 | 0.60, 0.49–0.73, 8 × 10−7 | East Asian: 0.66 § |
Sikorova et al. [9] | 2020 | Greece | Caucasian | 103/100 | Not available | Not available | 0.59, 0.39–0.89, 0.01 † | European: 0.42 |
Karakaya et al. | Netherlands | Caucasian | 262/363 | 0.30 | 0.41 | 0.61, 0.48–0.77, 3 × 10−5 | European: 0.42 |
* Odds ratio (OR), 95% confidence interval (CI), and p-values are calculated from the data provided in the original articles. # For correct presentation, the C and T allele are switched. § The gnomAD database shows that the T allele in East Asian is the major allele. Within the gnomAD database, the 1 KG shows different East Asian populations: Han Chinese in Beijing have a T allele frequency of 0.6373; Southern Han Chinese have a T allele frequency of 0.6619. † The genotype data were not available for the study by Sikorova et al.; values were copied from the original article.