Figure 3.

cASC and cASC-EV reduce the level of multiple inflammatory cytokines in atopic dermatitis-like skin lesions of Balb/c mice. (A) Tissue sections from the back skin and ears stained with Toluidine blue (TB). Red arrow indicates mast cell infiltrated into skin or ear tissue. Scale bar, 100 μm. (B) The number of mast cells counted from five random section areas (n = 6/group). (C) The expression of IL-4, IL-13, IL31, TSLP, RANTES and TARC genes on skin tissues as determined using real-time PCR (n = 6/group). The expression of TARC gene represent median [IQR] (min–max) and the others represent mean ± SD. Significant value was * p < 0.05, ** p < 0.01 vs. DNCB + Vehicle.