Table 1.
The role of resveratrol in numerous cancers through modulating various cell signaling pathways.
| Cancers | Finding/Outcome of the Study | Ref. |
|---|---|---|
| Head and neck cancer | Resveratrol enhanced the efficiency of cisplatin and irradiation and resultant decrease of cancer progression | [68] |
| Oral cancer | Adhesion of cancer cells treated with resveratrol was decreased and invasive abilities of cancer cells treated with resveratrol were decreased | [71] |
| Resveratrol inhibited cancer through induction of apoptosis | [73] | |
| Oesophagus cancer | Resveratrol inhibited cancer cell growth in a dose-dependent way through prompting cell cycle arrest | [75] |
| Treatment of cancer cells with resveratrol the PRs of Bcl-2 proteins were seemingly reduced | [77] | |
| Lung cancer | Apoptosis was induced in TRAIL-resistant lung cancer cells with a cotreatment of resveratrol | [78] |
| Resveratrol caused the tumor outcome via decreasing cell proliferation and promoting cell apoptosis | [79] | |
| Resveratrol concentration and time dependently reduced cancer cell viability | [80] | |
| Resveratrol synergistically increased the tumor effects of erlotinib | [81] | |
| Gastric cancer | Resveratrol inhibited the interleukin-6 induced cancer cell invasion | [82] |
| Resveratrol inhibited the growth of cancer cells through preventing the Wnt signaling pathway | [83] | |
| Resveratrol was able to significantly inhibit the viability of cancer cells | [84] | |
| Resveratrol-induced inhibition of cancer SNU-1 cell proliferation | [85] | |
| Gall bladder cancer | Resveratrol clearly decreased the proliferation in concentration as well as time-dependent manner and resveratrol induced apoptosis of tumor cells | [86] |
| Bile duct cancer | IL-6 indeed promoted the cell migration of invasive cancer cells; the resveratrol powerfully neutralized this effect both in cancer cells | [87] |
| Liver cancer | Resveratrol played a role in the inhibition of the proliferation and mobility of carcinoma cells via prompting autophagy | [88] |
| Prevention of cancer cell migration, tumor suppressor gene DLC1 Rho GTPase activating protein level was enhanced with resveratrol treatment | [56] | |
| Resveratrol importantly controlled tumor growth | [89] | |
| Resveratrol established a potential protective effect on cancer cells in a lipid overload state | [90] | |
| Pancreas cancer | Resveratrol- and apocynin-treated hamsters exhibited important decrease in the incidence of cancer | [91] |
| Resveratrol inhibited the cell proliferative ability in a dose- and time-dependent manner. | [92] | |
| Resveratrol treatment induced apoptosis, inhibited tumor growth, and increased the Bax expression | [93] | |
| Resveratrol derivative played role in the induction of dose-dependent apoptosis in cancer cell lines | [94] | |
| Colon cancer | Resveratrol induced cytotoxicity on cancer cells | [95] |
| Resveratrol efficiently inhibited cell proliferation and promoted cell apoptosis | [96] | |
| Resveratrol caused inhibition of cell proliferation interrelated with an induction of apoptosis | [97] | |
| Cancer cells exposed to resveratrol displayed meaningfully lower cyclooxygenase-2 and prostaglandin receptor expression | [98] | |
| PPARγ playe a role in resveratrol-induced apoptosis | [99] | |
| Renal cell carcinoma | Sitagliptin/resveratrol combination might signify a useful therapeutic modality for improvement of clear cell renal cell carcinoma | [100] |
| Resveratrol suppressed renal cell carcinoma and migration and promoted carcinoma apoptosis | [101] | |
| resveratrol suppressed renal cell carcinoma migration, cell proliferation, and invasion | [102] | |
| Resveratrol induced S-phase cell-cycle arrest and caused induction of apoptosis | [103] | |
| Prostate cancer | Resveratrol and its combination with bicalutamide significantly reduced cell viability | [104] |
| Resveratrol was able to downregulate the levels of the endogenously expressed ARV7 and androgen receptor target gene mRNAs in prostate cancer cells | [105] | |
| Resveratrol, DTX, and a combined drug treatment upregulated the proapoptotic genes | [64] | |
| Bladder cancer | Resveratrol was revealed to significantly inhibit the expression and secretion of matrix metalloproteinase-2 | [106] |
| Resveratrol decreased cell proliferation and induced DNA damage | [107] | |
| The effect of resveratrol on cancer cell apoptosis was due to miR-21 regulation of the Akt/Bcl-2 signaling pathway | [108] | |
| Resveratrol treatment decreased the expression of thevascular endothelial growth factor | [109] | |
| Breast cancer | Resveratrol-induced chemosensitivity, cell cycle, and apoptosis were arrested | [110] |
| Proanthocyanidins and resveratrol synergistically inhibited breast cancer cells via inducing apoptosis and modulating DNA methylation | [111] | |
| Suppression of EZH2 expression through ERK1/2 dephosphorylation was significant for the antiproliferative activities of resveratrol against breast cancer cells | [112] | |
| Cell cycle arrest, caspase activation as well apoptotic induction in cells treated with resveratrol-salinomycin combination established the efficiency of the combination | [113] | |
| Endometrial cancer | Resveratrol treatment inhibited the growth of cancer cells in a dose-dependent manner | [114] |
| Resveratrol arbitrated suppression of a functional activity of progesterone receptor as established by downregulation of alpha one integrin expression | [115] | |
| Cervix cancer | Resveratrol treatment with various concentrations caused increased cell cycle arrest | [116] |
| Resveratrol showed a role in the inhibition of both NF-κB and AP-1-mediated metalloproteinase-9 expression | [117] | |
| Long treatment of resveratrol induced cytosolic translocation of cytochrome c, caspase-3 activation, and apoptotic cell death | [118] | |
| Resveratrol pretreatment caused inhibition of cell division and induced an early S-phase cell-cycle checkpoint arrest | [119] | |
| Ovarian cancer | ARHI was expressed in low levels in ovarian cancer cell lines, which was enhanced after resveratrol treatment accompanied by growth arrest | [120] |
| Resveratrol analogues decreased the expression of epithelial mesenchymal transition markers | [121] | |
| Resveratrol induced apoptotic cell death in dose- and time-dependent manners | [122] | |
| Uterine cervix | Resveratrol inhibited cell proliferation in the cancer cell line, and the number of apoptotic cells increased in a resveratrol dose-dependent manner | [123] |
| Lymphoma | Resveratrol suppressed the phosphorylation level of AKT and Stat3 | [124] |
| Resveratrol played a role as proliferative and proapoptotic activity | [125] | |
| Resveratrol treatment increased reactive oxygen species generation, and the reactive oxygen species scavenger could decrease both the resveratrol-induced caspase-3 activity and the formation of acidic vacuoles | [126] | |
| Resveratrol induced caspase-dependent apoptosis via arresting cell-cycle progression | [127] | |
| Resveratrol played a role in the inhibition of protein synthesis, decreasing reactive oxygen species levels | [128] | |
| Myeloma | NEAT1 overexpression induced proliferation, migration, and invasion of multiple myeloma cells, although resveratrol neutralized its effect | [129] |
| Resveratrol caused proliferative activity in a dose- and time-dependent manner | [130] | |
| Resveratrol inhibited proliferation of myeloma cells in a dose- and time-dependent manner | [131] | |
| Melanoma | Resveratrol treatment inhibited proliferation and promoted melanogenesis of melanoma cells | [164] |
| Treatment of resveratrol in a tumor caused an increase in Cx43 gap junction communication and improved the combination of resveratrol and cisplatin therapeutic effects | [132] | |
| Resveratrol may assist as a pioneering therapeutic for melanoma treatment | [133] | |
| Resveratrol inhibited cancer cell proliferation and triggered apoptosis | [134] | |
| Leukemia | Resveratrol inhibited the proliferation as well as induced apoptosis | [135] |
| Resveratroled act as an autophagy modulator and an apoptosis inducer in human leukemia cells | [136] | |
| Resveratrol treatment upregulated the expression of PTEN and reduced the expression of p-AKT protein | [137] | |
| Osteosarcoma | Resveratrol inhibited cancer cell proliferation and tumorigenesis ability | [59] |
| Resveratrol suppressed the cancer cells by preventing the canonical Wnt signaling pathway | [138] | |
| Resveratrol inhibited the hypoxia-enhanced proliferation, epithelial to mesenchymal transition process, and the invasion in osteosarcoma | [139] | |
| Pro-poptotic effect of resveratrol might be improved by nutrition restriction elicited by l-asparaginase | [140] | |
| Thyroid cancer | Resveratrol enhanced cell death induced by (131)I on thyroid cancer cell | [141] |
| Resveratrol treatment suppressed thyroid carcinoma cell growth in a dose-dependent manner | [142] | |
| Glioblastoma | Resveratrol improved glioblastoma-initiating cells to temozolomide-induced apoptosis | [143] |
| Glioma | Resveratrol clearly inhibited EMT-induced self-renewal ability of glioma stem cells | [144] |
| Retinoblastoma | Resveratrol induced a dose- and time-dependent decrease in tumor cell viability and also caused inhibition of proliferation | [145] |