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. 2022 May 7;23(9):5230. doi: 10.3390/ijms23095230

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison between SHRSP5/Dmcr rats fed a standard diet (SD) or high-fat and high-cholesterol (HFC) diet for 8 weeks. (A) Representative macroscopic appearance of control (n = 4) and non-alcoholic steatohepatitis (NASH) (n = 4) livers. Scale bars = 1 cm. (B) The liver-to-body weight ratio in each group. (C) Aspartate transaminase (AST) and alanine transaminase (ALT) levels in plasma in each group. Values represent mean ± SD. Note: * p < 0.05 vs. control. (D) Hematoxylin–eosin- and Sirius Red-stained liver sections. Scale bars = 50 µm.