Skip to main content
. 2022 May 7;23(9):5230. doi: 10.3390/ijms23095230

Figure 6.

Figure 6

Schematic diagram of the miR-122-5p-mediated regulation of the Warburg effect in Kupffer cells during non-alcoholic steatohepatitis (NASH). The Warburg effect, particularly glycolysis, was activated in animal models of NASH. One of the main mechanisms underlying this activation was the upregulation of PKM2. Notably, dysregulation of miR-122-5p partially induced PKM2 upregulation, especially in Kupffer cells during NASH. These findings suggest that miRNA is strongly related to metabolic changes in carcinogenesis, even during the precancerous phase.