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. 2022 Apr 19;14(9):1634. doi: 10.3390/polym14091634

Table 5.

Antiviral activity of NAPs against different viruses with their mechanism of actions.

NAP Virus Cell Line Mechanism of Action Ref.
Phosphorothioate Oligonucleotides HIV-1 H9 Inhibiting viral entry to the host [119]
amphipathic DNA polymer (40-nucleotide polycytidine) HSV Human cervical epithelial (CaSki) Reduced viral and protein expression [120]
Amphipathic DNA polymers (REP 9, REP 2015 and REP 9C) Animal NIH 3T3 Reduced viral replication [123]
REP 2006 HBV DHBV Reduced viral entry to the host [126]
REP 2055 HBV DHBV blocking release of DHBsAg from the infected hepatocytes [128]