Table 6.
Antiviral activity of dendrimers and their mechanisms of action.
| Dendrimer Type | Name | Virus | Cell Line | Mechanism of Action | Ref. |
|---|---|---|---|---|---|
| Polyanionic | Phenyldicarboxylic acid (BRI6195), Naphthyldisulfonic acid (BRI2923) | HIV-1 | MT-4 | Inhibit viral binding and replication | [142] |
| Polyanionic | SPL-2999 | HSV-1, HSV-2 | Vero | Inhibit late stages of viral replication | [144] |
| Polyanionic | carbosilane dendrimer G2-STE16 | HIV-1 | TZM.bl | Inhibit viral entry | [151] |
| Polyanionic | G2-S16 | HIV | PBMC | Inhibit viral replication by blocking gp120/CD4/CCR5 interaction | [155] |
| Polyanionic | G3-S16 and G2-NF16 | HIV-1 | HeLa P4.R5MAGI, TZM.bl | Inhibit viral replication by blocking gp120/CD4/CCR5 interaction | [138] |
| Polycationic | Viologen | HIV-1 | MT-4 cells | Block viral entry | [152] |