Figure 1.

HLA presentation of tumor-associated antigenic peptides according to demographics and tumor characteristics. Number of (A) OvCa-associated and (B) MUC16-derived HLA class I-presented peptides, as well as (C) OvCa-associated and (D) MSLN-derived HLA class II-presented peptides identified by the immunopeptidome analysis of primary tumor tissue in relation to demographics and tumor characteristics, including age (left panel), nodal metastases (mid-left panel), distant metastases (mid-right panel) and tumor grading (right panel). Dots represent data from individual patients. Boxes represent the median and 25th to 75th percentiles, whiskers are minimum to maximum, Mann–Whitney U-test. Abbreviations: <55, age below 55 years; ≥55, age equal to or over 55 years; N −, no lymph node metastases; N +, lymph node metastases; M0, no sign of distant metastases; M1, distant metastases; G1/2, low/intermediate tumor grading; G3, high tumor grading; and p, p-value.