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ROC analysis for serum CA125, HE4 and ROMA for the detection of epithelial ovarian cancer. (A) Overall. CA125 AUC 0.927 (95%CI 0.892–0.961), HE4 AUC 0.927 (95%CI 0.897–0.957), ROMA AUC 0.959 (95%CI 0.937–0.980) p = <0.001. (B) Under 50. CA125 AUC 0.939 (95%CI 0.881–0.996), HE4 AUC 0.991 (95%CI 0.982–1.000), p = 0.06. (C) Over 50. CA125 AUC 0.936 (95%CI 0.901–0.972), HE4 AUC 0.869 (95%CI 0.817–0.921), p < 0.001.
