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ROC analysis for serum CA125, HE4 and ROMA for the detection of epithelial ovarian cancer by stage at diagnosis. (A) Early stage. CA125 AUC 0.845 (95%CI 0.771–0.919), HE4 AUC 0.854 (95%CI 0.791–0.917), ROMA AUC 0.906 (95%CI 0.856–0.956), p < 0.001. (B) Late stage. CA125 AUC 0.977 (95%CI 0.953–1.000), HE4 AUC 0.972 (95%CI 0.951–0.993), ROMA AUC 0.990 (95%CI 0.981–1.000), p = 0.006.
