Table 1.
Summary of biomarker and eGFR levels in women with and without ovarian cancer, stratified by age.
| Variable | No Ovarian Cancer | Ovarian Cancer | ||
|---|---|---|---|---|
| N = 1147 | N = 82 | |||
| Age < 50 Years | Age ≥ 50 Years | Age < 50 Years | Age ≥ 50 Years | |
| N = 622 | N = 525 | N = 18 | N = 64 | |
| Age (years) | ||||
| Mean (SD) | 37 (8.6) | 63 (10.1) | 44 (4.0) | 65 (9.5) |
| Serum CA125 (U/mL) | ||||
| Median (IQR) | 14 (10–21) | 11 (8–17) | 167 (50–2352) | 257 (85–961) |
| Negative result (n, %) | 562 (90) | 495 (94) | 3 (17) | 13 (20) |
| Positive result (n, %) | 60 (10) | 30 (6) | 15 (83) | 51 (80) |
| Serum HE4 (pmol/L) | ||||
| Median (IQR) | 53 (45–65) | 68 (55–96) | 284 (150–534) | 314 (107–742) |
| Negative result (n, %) | 550 (88) | 317 (60) | 0 (0) | 8 (12) |
| Positive result (n, %) | 72 (12) | 208 (40) | 18 (100) | 56 (88) |
| Combined results (n, %) | ||||
| Negative CA125 + HE4 | 498 (80) | 305 (59) | 0 (0) | 6 (9) |
| Positive CA125, negative HE4 | 51 (8) | 12 (2) | 0 (0) | 2 (3) |
| Positive HE4, negative CA125 | 65 (11) | 190 (36) | 3 (17) | 7 (11) |
| Positive CA125 + HE4 | 8 (1) | 18 (3) | 15 (83) | 49 (77) |
SD—standard deviation. n—number. IQR—interquartile range.