Table 3.
Overall sensitivity and specificity of serum HE4, CA125 (alone and in combination) and ROMA for the detection of ovarian cancer.
|
N = 1229 OC = 82 (7%) |
Sensitivity % (95%CI) | Specificity % (95%CI) | True Positive | False Positive |
|---|---|---|---|---|
| CA125 (≥35 U/mL) | 80.5 (70.3–88.4) | 92.2 (90.4–93.6) | 66 | 90 |
| HE4 (≥77pmol/L) | 90.2 (81.7–95.7) | (73.0–78.0) | 74 | 280 |
| Combination, either positive | 92.7 (84.8–97.3) | (67.3–72.6) | 76 | 344 |
| Combination, both positive | 78.0 (67.5–86.4) | 97.7 (96.7–98.5) | 64 | 26 |
| ROMA | 87.8 (78.7–94) | 80.8 (78.4–83.1) | 72 | 220 |
CI—confidence interval. n—number. OC—ovarian cancer. PPV—positive predictive value.