Table 6.
Sensitivity and specificity of HE4 using age-adjusted cut-offs for the diagnosis of ovarian cancer in women over and under 50 years of age.
| Sensitivity % (95%CI) | Specificity % (95%CI) | True Positive | False Positive | |
|---|---|---|---|---|
| a. Under 50 years of age (n = 640, OC = 18) | ||||
| CA125 (≥35 U/mL) | 83.3 (58.6–96.4) | 90.4 (87.8–92.6) | 15 | 60 |
| HE4 (≥68 pmol/L) | 100 (81.5–100) | 80.4 (77.0–83.4) | 18 | 122 |
| Combined, either positive | 100 (81.5–100) | 73.5 (69.8–76.9) | 18 | 165 |
| Combined, both positive | 83.3 (58.6–96.4) | 97.3 (95.7–98.4) | 15 | 17 |
| b. Over 50 years of age (n = 589, OC= 64) | ||||
| CA125 (≥35 U/mL) | 79.7 (67.8–88.7) | 94.3 (91.9–96.1) | 51 | 30 |
| HE4 (≥96 pmol/L) | 79.7 (67.8–88.7) | 74.7 (70.7–78.3) | 51 | 133 |
| Combined, either positive | 87.5 (76.8–94.4) | 71.8 (67.8–75.6) | 56 | 148 |
| Combined, both positive | 71.9 (59.2–82.4) | 97.1 (95.3–98.4) | 46 | 15 |
CI—confidence interval. PPV—positive predictive value.