Table 7.

Sensitivity and specificity of serum HE4, CA125 (alone and in combination) and ROMA for the detection of early- and late-stage ovarian cancer.

	Early Stage (I + II) n = 31		Late Stage (III + IV) n = 51
	Sensitivity % (95%CI)	Specificity % (95%CI)	Sensitivity % (95%CI)	Specificity % (95%CI)
CA125 (≥35 U/mL)	61.3 (42.2–78.2)	92.2 (90.4–93.6)	92.2 (81.1–97.8)	92.2 (90.4- 93.6)
HE4 (≥77 pmol/L)	80.6 (62.5–92.5)	75.6 (73.0–78.0)	96.1 (86.5–99.5)	75.6 (73.0–78.0)
Combined, either positive	83.9 (66.3–94.5)	70.0 (67.3–72.6)	98.0 (89.6–100.0)	70.0 (67.3–72.6)
Combined, both positive	58.1 (39.1–75.5)	97.7 (96.7–98.5)	90.2 (78.6–96.7)	97.7 (96.7–98.5)
ROMA	74.3 (55.4–88.1)	80.8 (78.4–83.1)	96.1 (86.5–99.5)	80.8 (78.4–83.1)

CI—confidence interval. n—number