Figure 11.

Aberrant mitochondria (aMt) in activated microglia cell(s) (MGCs) in the 20-week-old female diabetic db/db models. Panel A demonstrates a ramified MGC (rMGC) interacting with the neurovascular unit (NVU) in the control model. Panel B depicts an activated MGC (aMGC) with numerous aMt (pseudo-colored yellow with encircling red lines) in the diabetic db/db model. Note chromatin condensation (CC) within the nucleus (pseudo-colored red) (N). Panel C further depicts aMt and note that there is chromatin condensation within the pseudo-colored red nucleus (CC) in the female diabetic db/db model (panels B and C). Images provided by CC 4.0 [33,36]. CL = capillary lumen.