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. 2022 Apr 27;23(9):4820. doi: 10.3390/ijms23094820

Figure 22.

Figure 22

Aberrant mitochondria (aMt) in the obese, insulin resistant, diabetic db/db model vascular smooth muscle cell(s) (VSMCs) in the descending aorta. Panel A demonstrates the markedly electron-dense healthy mitochondria (Mt) in the cytoplasm of a non-proliferative VSMC. Panel B depicts a cluster of hyperlucent aberrant Mt (aMt) (encircled with yellow line) in the cytoplasm of a proliferative VSMC with loss of the electron-dense Mt matrix and loss of crista as compared to the control C57BLKS/J models in panel A. Original Magnification ×2500; intact scale bar = 0.5 μm. These images are exploded in a like manner with the scale bars intact to emphasize the normal control electron-dense Mt in panel A and the aMt in the db/db models in panel B. The original images for this figure are from the experiment with permission [69]. ECM = extracellular matrix.