Table 1.
IC50 values against 5α-reductase of the three isolated compounds (1–3) and two 5α-reductase inhibitors. The data are expressed as the means ± standard deviation (SD) of triplicate experiments.
| Samples | IC50 (µg/mL) | IC50 (µM) |
|---|---|---|
| Isolated Compounds | ||
| (+)-Eperua-8,13-dien-15-oic acid (1) | 4.31 ± 0.87 | 14.19 ± 2.87 a |
| (+)-Eperua-7,13-dien-15-oic acid (2) | 4.45 ± 0.10 | 14.65 ± 0.31a |
| Lupeol (3) | >170 | >400 |
| Positive controls [43] | ||
| Curcumin | 4.95 ± 0.15 | 13.40 ± 0.40 a |
| Finasteride | 0.28 ± 0.01 | 0.73 ± 0.03 b |
The mean values of IC50 (µM) from each sample were compared using one-way ANOVA followed by Duncan’s test. a, b Values not sharing the same letter are significantly different from another (p < 0.05).