Table 2.
Univariate followed by multivariate binary regression model for the prediction of follicle maturation after letrozole stimulation.
| Parameter | Letrozole Responsive Patients (n = 35) |
Letrozole Resistant Patients (n = 26) |
Crude OR (95%CI) | p | Adjusted OR (95% CI) | P |
|---|---|---|---|---|---|---|
| Age (years) 1 | 28.1 ± 4.5 | 27.8 ± 3.8 | 1.02 (0.90; 1.15) | 0.776 | - | - |
| BMI (kg/m2) 1 | 26.5 ± 4.4 | 25.8 ± 5.7 | 1.03 (0.93; 1.14) | 0.610 | - | - |
| Obesity 2 | 8 (22.9) | 5 (19.2) | 1.24 (0.36; 4.37) | 0.733 | - | - |
| Duration of infertility (months) 1 | 35.8 ± 21.2 | 24.4 ± 17.5 | 1.03 (1.00; 1.06) | 0.037 | 1.02 (0.98; 1.05) | 0.386 |
| Secondary infertility 2 | 8 (22.9) | 8 (30.8) | 0.67 (0.21; 2.1) | 0.488 | - | - |
| Insulin resistance 2 | 7 (20.0) | 7 (26.9) | 0.68 (0.21; 2.25) | 0.526 | - | - |
| Myoinositol treatment 2 | 14 (40.0) | 17 (65.4) | 0.353 (0.12; 1.01) | 0.053 | - | - |
| Metformin treatment 2 | 6 (17.1) | 5 (19.2) | 0.869 (0.23; 3.23) | 0.834 | - | - |
| Polycystic ovarian morphology 2 | 23 (65.7) | 24 (92.3) | 0.16 (0.03; 0.79) | 0.025 | 0.30 (0.05; 1.69) | 0.172 |
| LH to FSH ratio 1 | 1.8 ± 1.2 | 2.1 ± 0.8 | 0.77 (0.47; 1.26) | 0.290 | - | - |
| Testosterone (ng/mL) 1 | 0.37 ± 0.18 | 0.47 ± 0.24 | 0.08 (0.01; 1.19) | 0.066 | - | - |
| AMH (ng/mL) 1 | 5.0 ± 3.2 | 9.7 ± 4.7 | 0.73 (0.61; 0.87) | <0.001 | 0.76 (0.63; 0.92) | 0.005 |
| 25OHD3 (nmol/L) 1 | 62.5 ± 32.1 | 65.4 ± 30.9 | 1.00 (0.98; 1.01) | 0.719 | - | - |
| 25OHD3 < 25 nmol/L 2 | 3 (8.6) | 3 (11.5) | 0.72 (0.13; 3.89) | 0.701 | - | - |
| Parathyroid hormone (pg/mL) 1 | 38.4 ± 19.7 | 39.6 ± 16.2 | 1.00 (0.97; 1.03) | 0.825 | - | - |
| Serum calcium (mmol/L) 1 | 2.36 ± 0.08 | 2.37 ± 0.12 | 0.23 (0.00; 72.87) | 0.614 | - | - |
| Serum protein (g/L) 1 | 70.2 ± 13.3 | 74.0 ± 3.7 | 0.89 (0.76; 1.04) | 0.154 | - | - |
| Albumin (g/L) 1 | 46.6 ± 2.4 | 46.9 ± 2.7 | 0.96 (0.76; 1.20) | 0.695 | - | - |
| Magnesium (mmol/L) 1 | 0.80 ± 0.06 | 0.81 ± 0.06 | 0.08 (0.00; 806.17) | 0.596 | - | - |
| Phosphorus (mmol/L) 1 | 1.04 ± 0.13 | 1.11 ± 0.16 | 0.04 (0.01; 2.14) | 0.110 | - | - |
| Calcium phosphorus product (mmol2/L2) 1 | 2.48 ± 0.32 | 2.62 ± 0.40 | 0.31 (0.06; 1.62) | 0.165 | - | - |
Data are provided as 1 mean ± standard deviation or 2 number (frequency), n = number, OR = odds ratio, BMI = body mass index, LH = luteinizing hormone, FSH = follicle stimulating hormone, 25OHD3 = 25-hydroxyvitamin D3, AMH = anti-Müllerian hormone.