Table 1.
Distribution of FIB-4 index in those who received abdominal ultrasonography at health checkups in Japan
| Age (years) | N | FIB-4 index | ||||||
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | Median | Min–Max | FIB4-index < 1.30 (%) | FIB4-index ≥ 2.67 (%) | Cochran-Armitage test for the proportion of FIB-4 index ≥ 2.67 by age group | |||
| Total population who received ultrasonography (N = 75,666) | < 50 | 32,103 | 0.82 ± 0.31 | 0.62 | 0.18–12.07 | 93.3 | 0.2 | p < 0.0001 |
| 50–59 | 20,868 | 1.23 ± 0.44 | 1.16 | 0.17–15.39 | 68.9 | 0.8 | ||
| 60–69 | 16,854 | 1.60 ± 0.66 | 1.50 | 0.34–32.48 | 31.0 | 3.8 | ||
| ≥ 70 | 5841 | 2.10 ± 0.75 | 1.97 | 0.23–15.40 | 7.8 | 16.4 | ||
| Overall | 75,666 | 1.20 ± 0.63 | 1.07 | 0.17–32.48 | 65.3 | 2.3 | ||
| Non-drinkers without fatty liver (N = 47,222) | < 50 | 20,133 | 0.82 ± 0.28 | 0.78 | 0.21–6.64 | 94.9 | 0.1 | p < 0.0001 |
| 50–59 | 11,946 | 1.24 ± 0.40 | 1.18 | 0.22–5.97 | 62.3 | 0.7 | ||
| 60–69 | 10,649 | 1.61 ± 0.63 | 1.53 | 0.44–32.48 | 27.9 | 3.4 | ||
| ≥ 70 | 4494 | 2.13 ± 0.75 | 2.01 | 0.23–15.40 | 6.8 | 17.3 | ||
| Overall | 47,222 | 1.23 ± 0.63 | 1.10 | 0.21–32.48 | 63.2 | 2.3 | ||
| Non-drinkers with fatty liver (NAFLD) (N = 17,968) | < 50 | 6934 | 0.75 ± 0.31 | 0.71 | 0.18–12.07 | 96.4 | 0.1 | p = 0.0008 |
| 50–59 | 5559 | 1.13 ± 0.38 | 1.06 | 0.33–4.34 | 73.7 | 0.5 | ||
| 60–69 | 4350 | 1.48 ± 0.66 | 1.38 | 0.34–26.70 | 41.9 | 2.7 | ||
| ≥ 70 | 1125 | 1.92 ± 0.66 | 1.82 | 0.58–7.02 | 11.9 | 10.3 | ||
| Overall | 17,968 | 1.12 ± 0.58 | 1.01 | 0.18–26.70 | 70.9 | 1.6 | ||
SD standard deviation, NAFLD non-alcoholic fatty liver disease
The proportion of FIB-4 index ≥ 2.67, high risk of liver fibrosis, were compared by age group by the Cochran-Armitage test