Table 2.
EGFR mutation types co-occurring with FGFR2/3 fusions in the Guardant Health electronic database.
| FGFR Fusion Type | EGFR Sensitizing Mutation Type | EGFR Resistance Mutation Type | ||||||
|---|---|---|---|---|---|---|---|---|
| Exon 19 Deletion, n (%) |
L858R, n (%) |
L861Q, n (%) |
Total, n (%) |
T790M, n (%) |
C797X, n (%) |
T790M and C797X, n (%) |
None, n (%) |
|
| FGFR2-CCDC6 | 1 (2.6) | 0 (0) | 0 (0) | 1 (2.6) | 1 (2.6) | 0 (0) | 0 (0) | 0 (0) |
| FGFR2-KIAA1598 | 1 (2.6) | 1 (2.6) | 0 (0) | 2 (5.1) | 1 (2.6) | 0 (0) | 0 (0) | 1 (2.6) |
| FGFR2-TACC2 | 0 (0) | 1 (2.6) | 0 (0) | 1 (2.6) | 1 (2.6) | 0 (0) | 0 (0) | 0 (0) |
| FGFR3-TACC3 | 23 (58.9) | 11 (28.2) | 1 (2.6) | 35 (89.7) | 5 (12.8) | 1 (2.6) | 7 (17.9) | 22 (56.4) |
| Total | 25 (64.1) | 13 (33.3) | 1 (2.6) | 39 (100) | 8 (20.5) | 1 (2.6) | 7 (17.9) | 23 (59.0) |
Abbreviations: EGFR—epidermal growth factor receptor; FGFR—fibroblast growth factor receptor.