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. 2022 Apr 25;23(9):4744. doi: 10.3390/ijms23094744

Figure 3.

Figure 3

The levels of brain insulin signaling markers and tau phosphorylated at threonine 231 residue in the hippocampus of WT C57BL/6J mice. (A) Quantification and statistical analysis. (B) Representative source Western blots. Statistical analysis comprised the Shapiro–Wilk normality test, two-way ANOVA, and Tukey’s post hoc test; significant results: p-IRS-1 (Ser616): (4M WD vs. 8M WD (p-Value = 0.0108); 8M WD vs. 16M WD (p-Value: 0.0003); p-GSK-3β (Ser9): (4M CTR vs. 8M CTR (p-Value = 0.0372)); p-Tau (Thr231): (8M CTR vs. 12M CTR (p-Value < 0.0001)). The source figures from Western blot analysis are attached in Appendix A: Figure A2a,b; Completed statistical data in Supplementary Materials Table S2).