Table 1.

Flavanols: Table showing the experimental method (type of nerve injury and animal model), the dose, and method of administration of epigallocatechin gallate (EGCG) and green tea extract (GTP). Included references are listed ascending in accordance to their publication date.

Epigallocatechin Gallate
Ref.	Type of Nerve Lesion and Animal Model	Type of Administration/Experimental Groups
Kian et al., 2019 [29]	Sciatic nerve transection; male Sprague Dawley rats	-Sham-operated rats; -Sciatic nerve transaction with saline (vehicle); -50 mg/kg of EGCG intraperitoneally 30 min before nerve transection and followed for 3 days; -50 mg/kg of EGCG intraperitoneally 1 h after nerve transection and followed for 3 days.
Renno et al., 2017 [26]	Sciatic nerve crush injury; male Wistar rats	-Control (no injury); -Sham-operated rats; -Crush + saline-treated rats; -Crush + 50 mg/kg; -Intraperitoneal injection of EGCG or saline daily for 3 days starting 1 h after nerve injury.
Renno et al., 2016 [28]	Sciatic nerve crush injury; male Wistar rats	-Control (no injury); -Sham-operated rats; -Crush + saline-treated rats; -Crush + 50 mg/kg EGCG; -Intraperitoneal injection of EGCG or saline daily starting 1 h after nerve injury until sacrifice.
Yildirim et al., 2014 [27]	Sciatic nerve crush injury; male Albino Wistar rats	-Control (no injury); -Injury without treatment; -Intraperitoneal injection of saline for 7 days; -Intraperitoneal injection of 25 mg/kg EGCG for 7 days; -Intraperitoneal injection of 50 mg/kg EGCG for 7 days; -Daily consumption group (intraperitoneal injection of 10 mg/kg EGCG for 14 days before injury). Samples were harvested at 28 days after injury.
Renno et al., 2013 [25]	Sciatic nerve crush injury; male Wistar rats	-Sham-operated rats; -Crush + saline-treated; -Crush + 50 mg/kg EGCG. Intraperitoneal injection of EGCG or saline daily for 3 days starting 1 h after nerve injury.
Renno et al., 2012 [24]	Sciatic nerve crush injury; male Wistar rats	-Sham-operated rats; -crush + saline-treated; -crush + 50 mg/kg EGCG; Intraperitoneal injection of EGCG or saline 1 h after nerve injury, and days 1 and 2 post-surgery.
Wei et al., 2011 [30]	Left vagus and hypoglossal nerve crush injury; male Wistar rats	-Sham-operated rats; -Injury without treatment; -10 mg/kg EGCG pretreatment; -25 mg/kg EGCG pretreatment; -50 mg/kg EGCG pretreatment. Daily intraperitoneal injections of EGCG for successive six days with the last injection at 30 min before injury.
Green tea extract
Chen et al., 2020 [37]	Sciatic nerve end-to-end repair; male Wistar rats	-Vehicle group: intraperitoneally injected with saline for 2 weeks; -Green tea group: intraperitoneally injected with GTPs (50 mg/kg/d) for 2 weeks.
Zhou et al., 2015 [36]	10 mm-long sciatic nerve defect repaired with allograft; male Wistar rats	-Autograft; -Fresh nerve allograft; -Irradiation-pretreated nerve allograft (26.39 Gy/min for 12 h); -Green tea polyphenol-pretreated nerve allograft: nerve segments immersed in DMEM solution containing polyphenol (1 mg/mL) for 1 week and in DMEM solution for a subsequent 3 weeks at 4 °C.
Nakayama et al., 2010 [35]	30 mm-long ulnar nerve defect repaired with allograft; male and female beagle dog	Nerve fascicles from male dog stored in DMEM containing polyphenol (1 mg/mL) for one week and then transferred to DMEM solution alone for three weeks. These nerve segments were used to repair the right female ulnar nerves. The left ones were repaired with autograft.After nerve repair, the immunosuppressant FK506 administration was started one day before the transplantation, at different doses: -Subcutaneous injections of 0.1 mg/kg FK506 every day; -Subcutaneous injections of 0.05 mg/kg FK506 every day; -Subcutaneous injections of 0.05 mg/kg FK506 every other day.
Ikeguchi et al., 2005 [34]	15 mm-long sciatic nerve defect repaired with allograft; inbred Lewis rats and male Dark Agouti rats	-Isograft group: nerve segments harvested from male Lewis rats and immediately transplanted into male Lewis rats. -Polyphenol-treated isograft group: nerve segments harvested from male Lewis rats. -Stored in DMEM containing polyphenol (1 mg/mL) for 4 weeks, and then in DMEM solution alone for 2 days and transplanted into male Lewis rats; -Fresh allograft group: nerve segments harvested from male DA rats and immediately transplanted into male Lewis rats.
Matsumoto et al., 2005 [33]	15 mm-long sciatic nerve defect repaired with allograft; inbred Lewis rats	-Fresh nerve graft group (immediate repair with nerve segment). -Nerve deficit group (no repair). -Nerve segments used to repair the nerve gap were treated with different concentrations of polyphenols for different periods of immersion: -1.0 mg/mL polyphenol for 1 day and then in DMEM for 27 days at 4 °C; -1.0 mg/mL polyphenol for 1 week and then in DMEM for 3 weeks at 4 °C; -1.0 mg/mL polyphenol for 4 weeks and then in DMEM for 2 days at 4 °C; -0.5 mg/mL polyphenol for 1 day and then in DMEM for 27 days at 4 °C; -0.5 mg/mL polyphenol for 1 week and then in DMEM for 3 weeks at 4 °C; -0.5 mg/mL polyphenol for 4 weeks and then in DMEM for 2 days at 4 °C; -2.5 mg/mL polyphenol for 1 day and then in DMEM for 27 days at 4 °C; -2.5 mg/mL polyphenol for 1 week and then in DMEM for 3 weeks at 4 °C; -2.5 mg/mL polyphenol for 4 weeks and then in DMEM for 2 days at 4 °C.
Ikeguchi et al., 2003 [32]	15 mm-long sciatic nerve defect repaired with allograft; male (donor) and female (recipient) Lewis rats	-Nerve segments removed and transplanted without any storage; -Nerve segments immersed in DMEM solution containing polyphenol (1 mg/mL) for 1 week and in DMEM solution for a subsequent 3 weeks at 4 °C; -Nerve segments immersed in DMEM solution for 4 weeks at 4 °C.