Skip to main content
. 2022 May 5;23(9):5177. doi: 10.3390/ijms23095177

Table 2.

Flavanones: Table showing the experimental method (type of nerve injury and animal model), the dose, and the method of administration of hesperidin (Hes) and naringenin. Alg/Chit—Alginate/Chitosan. Included references are listed ascending in accordance to their publication date.

Hesperidin
Ref. Type of Nerve Lesion and Animal Model Type of Administration/Experimental Groups
Bagher et al., 2020 [38] Sciatic nerve crush injury;
adult male Wistar rats
  • -

    Negative control (injury but no surgical interventions);

  • -

    Positive control (no injury);

  • -

    Alg/Chit hydrogel;

  • -

    Alg/Chit/0.1%Hes;

  • -

    Alg/Chit/1%Hes;

  • -

    Alg/Chit/10%Hes;

Hesperidin (0.1%, 1%, and 10% (w/v)) was loaded into cross-linked alginate/chitosan hydrogel. The hydrogel was injected to the site of the crush injury.
Naringenin
Ebrahimi et al., 2020 [42] Sciatic nerve crush injury;
male adult Wistar rats
  • -

    Negative control (injury without treatment);

  • -

    Positive control (rats without injury);

  • -

    Treatment with Alg/Chit hydrogel;

  • -

    Treatment with Alg/Chit hydrogel containing Berberine (Ber)-loaded Cs;

  • -

    Nanoparticles (NPs);

  • -

    Treatment with Alg/Chit hydrogel containing Naringin (Nar)-loaded Cs NPs;

  • -

    Treatment with Alg/Chit hydrogel containing both Ber and Nar NPs.

The hydrogel was injected into the site of crush injury.
Oliveira et al., 2020 [43] Sciatic nerve crush injury;
male Swiss mice
  • -

    Sham group;

  • -

    Vehicle (saline + tween 0.4% v/v);

  • -

    Naringenin (50 mg/kg);

  • -

    Naringenin complexed with hydroxypropyl-β-cyclodextrin (50 mg/kg).

Treatment started 24 h after surgery, by oral gavage, for 28 consecutive days.
Samadian et al., 2019 [41] Sciatic nerve crush injury;
male Wistar rats
  • -

    Collagen type I hydrogel with naringin;

  • -

    Collagen type I hydrogel without naringin;

  • -

    Negative control (injury without treatment);

  • -

    Autograft group (positive control).

The hydrogel was injected into the site of crush injury.