Chen et al., 2017 [49] |
Sciatic nerve crush injury; male C57BL/6J mice |
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Quercetin 0.2 mg·kg-1·day-1 (low dose)
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Quercetin 2 mg·kg-1·day-1 (medium dose)
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Quercetin 20 mg·kg-1·day-1 (high dose)
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mNGF 4.86 μg·kg-1·day-1
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saline (vehicle group)
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sham group
Injection in the plantar muscle on the left hindlimb once daily with a volume of 0.1 ml, starting after nerve injury and for 7, 14 or 35 days. |
Huang et al., 2020 [53] |
The C5–C7 nerve roots avulsion; C6 anterior root resection and positioning of the posterior root above the anterior root; female Sprague Dawley rats |
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Control;
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Hydrogel;
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5 mg/mL quercetin-loaded hydrogel;
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10 mg/mL quercetin-loaded hydrogel;
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50 mg/mL quercetin-loaded hydrogel;
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100 mg/mL quercetin-loaded hydrogel.
In situ injections of PLGA-PEG-PLGA hydrogel loaded with different concentrations of quercetin. |
Qiu et al., 2019 [50] |
Sciatic nerve crush; male ICR mice |
|
Turedi et al., 2018 [51] |
sciatic nerve crush; Sprague Dawley rats |
Quercetin (200 mg/kg) was administered intragastrically for 7 days or 28 days. |
Thipkaew et al., 2017 [52] |
Sciatic nerve crush; Wistar male rats with streptozotocin (STZ)-induced diabetes |
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DM + crush injury and no treatment;
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DM + crush injury + zein-based nanofiber mats treatment;
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DM + crush injury + zein-based nanofiber loaded with 5% quercetin;
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DM + crush injury + zein-based nanofiber loaded with 10% quercetin;
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DM+ crush injury + zein-based nanofiber loaded with 15% quercetin.
|
Wang et al., 2011 [48] |
15 mm rat sciatic nerves gap; adult Sprague Dawley rats |
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Silicon rubber chamber filled with saline;
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Silicon rubber chamber filled with 0.1 µg/mL QC solution;
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Silicon rubber chamber filled with 1 µg/mL QC solution;
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Silicon rubber chamber filled with 10 µg/mL QC solution.
|
Myricetin
|
Zhang et al., 2018 [62] |
Sciatic nerve crush injury; Sprague Dawley rats |
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Saline group;
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Nerve injury, treated with equivalent volumes of saline;
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Nerve injury + myricetin 25 mg/Kg;
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Nerve injury + myricetin 50 mg/Kg;
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Nerve injury + myricetin 100 mg/Kg.
Treatment groups received Myricetin via oral gavage every day for 14 days. |