Skip to main content
. 2022 May 5;23(9):5177. doi: 10.3390/ijms23095177

Table 3.

Flavonols: Table showing the experimental method (type of nerve injury and animal model), the dose, and method of administration of quercetin and myricetin. PLGA-PEG-PLGA—poly (D,L-lactide-co-glycolide)-poly(ethylene-glycol)-poly(D,L-lactide-co-glycolide) hydrogel. Included references are listed ascending in accordance to their publication date.

Quercetin
Ref. Type of Nerve Lesion and Animal Model Type of Administration/Experimental Groups
Chen et al., 2017 [49] Sciatic nerve crush injury;
male C57BL/6J mice
  • -

    Quercetin 0.2 mg·kg-1·day-1 (low dose)

  • -

    Quercetin 2 mg·kg-1·day-1 (medium dose)

  • -

    Quercetin 20 mg·kg-1·day-1 (high dose)

  • -

    mNGF 4.86 μg·kg-1·day-1

  • -

    saline (vehicle group)

  • -

    sham group

Injection in the plantar muscle on the left hindlimb once daily with a volume of 0.1 ml, starting after nerve injury and for 7, 14 or 35 days.
Huang et al., 2020 [53] The C5–C7 nerve
roots avulsion;
C6 anterior root resection and positioning of the posterior root above the anterior root;
female Sprague Dawley rats
  • -

    Control;

  • -

    Hydrogel;

  • -

    5 mg/mL quercetin-loaded hydrogel;

  • -

    10 mg/mL quercetin-loaded hydrogel;

  • -

    50 mg/mL quercetin-loaded hydrogel;

  • -

    100 mg/mL quercetin-loaded hydrogel.

In situ injections of PLGA-PEG-PLGA hydrogel loaded with different concentrations of quercetin.
Qiu et al., 2019 [50] Sciatic nerve crush;
male ICR mice
  • -

    Sham-operated group;

  • -

    Sciatic nerve crush + intraperitoneal injection of saline;

  • -

    Sciatic nerve crush + intraperitoneal injection of isoquercitrin (20 mg/kg/day).

Turedi et al., 2018 [51] sciatic nerve crush;
Sprague Dawley rats
  • -

    Sham-operated group;

  • -

    Quercetin group (200 mg/kg);

  • -

    Crush injury;

  • -

    Crush injury + quercetin (200 mg/kg).

Quercetin (200 mg/kg) was administered intragastrically for 7 days or 28 days.
Thipkaew et al., 2017 [52] Sciatic nerve crush;
Wistar male rats with streptozotocin (STZ)-induced diabetes
  • -

    DM + crush injury and no treatment;

  • -

    DM + crush injury + zein-based nanofiber mats treatment;

  • -

    DM + crush injury + zein-based nanofiber loaded with 5% quercetin;

  • -

    DM + crush injury + zein-based nanofiber loaded with 10% quercetin;

  • -

    DM+ crush injury + zein-based nanofiber loaded with 15% quercetin.

Wang et al., 2011 [48] 15 mm rat sciatic nerves gap; adult Sprague Dawley rats
  • -

    Silicon rubber chamber filled with saline;

  • -

    Silicon rubber chamber filled with 0.1 µg/mL QC solution;

  • -

    Silicon rubber chamber filled with 1 µg/mL QC solution;

  • -

    Silicon rubber chamber filled with 10 µg/mL QC solution.

Myricetin
Zhang et al., 2018 [62] Sciatic nerve crush injury;
Sprague Dawley rats
  • -

    Saline group;

  • -

    Nerve injury, treated with equivalent volumes of saline;

  • -

    Nerve injury + myricetin 25 mg/Kg;

  • -

    Nerve injury + myricetin 50 mg/Kg;

  • -

    Nerve injury + myricetin 100 mg/Kg.

Treatment groups received Myricetin via oral gavage every day for 14 days.