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. 2022 May 5;23(9):5177. doi: 10.3390/ijms23095177

Table 5.

Hydroxybenzoic derivatives: Table showing the experimental method (type of nerve injury and animal model), the dose, and method of administration of gallic acid. Included references are listed ascending in accordance to their publication date.

Gallic Acid
Ref. Type of Nerve Lesion and Animal Model Type of Administration/Experimental Groups
Gurkan et al., 2021 [87] Sciatic nerve end-to-end repair;
male albino Sprague Dawley
  • -

    Control (no injury);

  • -

    Surgery + saline (1 mL/kg/day 0.9% NaCl);

  • -

    Surgery + gallic acid (20 mg/kg/day).

Gallic acid was administered intraperitoneally following the surgery, for 12 weeks.
Hajimoradi et al., 2014 [86] Sciatic nerve crush;
male Wistar rats
  • -

    Control: intact rats received normal saline (2 mL/kg);

  • -

    Crush + saline (2 mL/kg);

  • -

    Crush + 50 mg/kg/2 mL gallic acid (GA);

  • -

    Crush + 100 mg/kg/2 mL GA;

  • -

    Crush + 200 mg/kg/2 mL GA;

  • -

    Crush + forced exercise;

  • -

    Crush + forced exercise combined with 200 mg/kg/2 mL GA as an effective dose for 21 days. Gallic acid was administered orally (dissolved in 2 mL/1000 g body weight normal saline) at different doses every day starting from the 2nd day after nerve crush for 21 days, alone and in combination with exercise.