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. 2022 May 5;23(9):5177. doi: 10.3390/ijms23095177

Table 7.

Lignans: Table showing the experimental method (type of nerve injury and animal model), the dose, and method of administration of flaxseed oil and sesame oil.

Flaxseed Oil
Ref. Type of Nerve Lesion and Animal Model Type of Administration/Experimental Groups
Danial et al., 2020 [113] Sciatic nerve crush injury;
male Sprague Dawley rats
  • -

    No injury;

  • -

    Negative control: daily oral administration of distilled water (10 mL/kg body weight per day);

  • -

    Experimental group: administered with flaxseed oil (1000 mg/kg body weight per day);

  • -

    Positive control: administered with mecobalamin (130 µg/kg body weight per day) using esophageal feeding tube for 28-day post-operation period.
Sesame Oil
Hsu et al., 2016 [114] Sciatic nerve crush;
male SPF C57BL/6 mice
  • -

    Sham group;

  • -

    Negative control (injury without treatment);

  • -

    0.5 mL/kg of sesame oil for 6 days after injury;

  • -

    1 mL/kg of sesame oil for 6 days after injury;

  • -

    2 mL/kg of sesame oil for 6 days after injury.

Mice were fed daily with sesame oil using an ingestion tube.