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. 2022 May 5;23(9):5177. doi: 10.3390/ijms23095177

Table 8.

Stilbenes: Table showing the experimental method (type of nerve injury and animal model), the dose, and method of administration of resveratrol. Included references are listed ascending in accordance to their publication date.

Resveratrol
Ref. Type of Nerve Lesion and Animal Model Type of Administration/Experimental Groups
Zhang et al., 2020 [123] Crush injury of sciatic nerve; Sprague Dawley rats
  • -

    Sham;

  • -

    Crush injury;

  • -

    Crush injury + resveratrol (100 mg/kg) intraperitoneally injected daily for 7 days after injury;

  • -

    Crush injury + 3-methyladenine (autophagy inhibitor), (50 mg/kg) intraperitoneally injected daily for 7 days after injury.

Nerves were harvested 14 days after crush injury.
Revin et al., 2019 [124] Cut of sciatic nerve; adult Wistar rats First set of experiment:
  • -

    Control nerves without electrical stimulation;

  • -

    Nerves stimulated with an alternating electric current of 100 imp/s for 5 min.

Second set of experiment:
  • -

    Sciatic nerves were injured by cutting and sutured;

  • -

    Sciatic nerve injured, cut, and perfused daily in the cutting area with trans-resveratrol, 100 uL 0.1 M.

Proximal and distal parts of the sciatic nerves were harvested 7 days after injury.
Ding et al., 2018 [118] Sciatic nerve crush injury; adult male Sprague Dawley rats
  • -

    Crush-injured group;

  • -

    Control vehicle 2% v/v DMSO in saline solution;

  • -

    Resveratrol-treated group: 50 mg/kg intraperitoneal daily for 10 days after injury;

  • -

    Resveratrol-treated group: 200 mg/kg intraperitoneal daily for 10 days after the crush injury.
Bagriyanik et al., 2014 [119] Chronic constriction injury of sciatic nerve; male Wistar rats
  • -

    Sham group;

  • -

    CCI + saline group;

  • -

    CCI + resveratrol intraperitoneal injection 10 mg/kg once a day for 14 days, starting the 1st day after injury;

  • -

    CCI + saline group was injected with vehicle (5% ethanol in saline).