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. 2022 Apr 21;23(9):4583. doi: 10.3390/ijms23094583

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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GOT1/2 mediates amino acid metabolism regulated by HGD/GSTZ1. (A,B) The core-enriched signaling pathways in high and low HGD or GSTZ1 groups. NES, normalized enrichment score. (C,D) GSEA pathway enrichment analyses of HGD or GSTZ1 signature in patients with RCC from the TCGA datasets. (E) The overlapping analysis for related genes of amino acid metabolism in RCC patients. (F,G) The core-enriched signaling pathways in high and low GOT1 or GOT2 groups. NES, normalized enrichment score. (H) The mRNA and protein expression levels of GOT1 and GOT2 between tumor and normal tissues in patients with KIRC in TGCA database. (I) The expression correlation between HGD/GSTZ1 and GOT1/GOT2. *** p < 0.001.