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. 2022 Apr 21;23(9):4583. doi: 10.3390/ijms23094583

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Down-regulation of HGD and GSTZ1 may serve as a potential diagnostic biomarker in KIRC. (A) The key regulator (HGD, GSTZ1, GOT1, and GOT2) mRNA expression levels between different grades of tumor and normal tissues in patients with KIRC in TGCA database. (B) Overall survival of patients with KIRC grouped by GOT1 and GOT2 expression through GEPIA web server. (C) ROC curve analysis indicated that the key regulator (HGD, GSTZ1, GOT1, and GOT2) could efficiently distinguish KIRC from normal individual. AUC, the area under curve. (D) Proposed model: The role and mechanism of HGD and GSTZ1 in KIRC progression.

Down-regulation of HGD and GSTZ1 may serve as a potential diagnostic biomarker in KIRC. (A) The key regulator (HGD, GSTZ1, GOT1, and GOT2) mRNA expression levels between different grades of tumor and normal tissues in patients with KIRC in TGCA database. (B) Overall survival of patients with KIRC grouped by GOT1 and GOT2 expression through GEPIA web server. (C) ROC curve analysis indicated that the key regulator (HGD, GSTZ1, GOT1, and GOT2) could efficiently distinguish KIRC from normal individual. AUC, the area under curve. (D) Proposed model: The role and mechanism of HGD and GSTZ1 in KIRC progression.