Domains	Yes	No	Not Addressed	Not Applicable
Study purpose	Yes	No	Na	NA
1. Was the purpose stated clearly?
Literature review	Yes	No	Na	NA
2. Was relevant background literature reviewed?
Sample	Yes	No	Na	NA
3. Was the sample described in detail?
4. Was sample size justified?
5. Were the groups randomized?
6. Was randomization appropriately done?
Outcome	Yes	No	Na	NA
7. Were the outcome measures reliable?
8. Were the outcome measures valid?
Results	Yes	No	Na	NA
9. Were results reported in terms of statistical significance?
10. Were the analysis of method(s) appropriate?
11. Was clinical importance reported?
12. Were drop-outs reported?
Conclusions	Yes	No	Na	NA
13. Were conclusions appropriate, given study methods and results?