AKT	phosphatidylinositol 3-kinase (PI3K)/protein kinase B
AMPK	AMP-activated protein kinase
CRISP	cysteine-rich secretory protein
CSC	cancer stem cell
DEN	diethylnitrosamine
D-PDMP	D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol
DSGG	disialosyl galactosyl globoside
EpCAM	epithelial cellular adhesion molecule
ER	endoplasmic reticulum
ERT	enzyme replacement therapy
GBA	glucocerebrosidase
GBA3	glucosylceramidase beta 3
Gb3	globotriaosylceramide
GEMs	glycosphingolipid-enriched microdomains
GlcCer	glucosylceramide
GM3	monosialodihexosylganglioside
GSLs	glycosphingolipids
HCC	Hepatocellular carcinoma
HDAC2	histone deacetylase 2
KEGG	Kyoto Encyclopedia of Genes and Genomes
KO	knockout
LCSC	liver cancer stem cell
lyso-GlcCer	glucosylsphingosine
MAPK	mitogen-activated protein kinase
mTOR	mechanistic Target of Rapamycin
NASH	non-alcoholic steatohepatitis
OE	Overexpression
ORMDL3	ORMDL sphingolipid biosynthesis regulator 3
RAF	rapidly accelerated fibrosarcoma
S1P	sphingosine-1-phosphate
SIN3B	paired amphipathic helix protein
SRT	substrate reduction therapy
TCGA	The Cancer Genome Atlas
UGCG	UDP-glucose ceramide glycosyltransferase