Figure 2.

Metabolic strategies to control fibrosis could be based on inhibiting glycolysis, fatty acid, and pyruvate oxidation. Glycolysis can be modulated by inhibiting hexokinase 2 by 2-deoxyglucose, though the safety of this approach must be proved. The alternative strategy is coupling glycolysis with the Krebs cycle by inhibiting PDH Kinase using DCA or increasing PDH activity by reducing the intramitochondrial acetyl-CoA pool using L-carnitine.