Table 2.
Other potential resistance conferring mutations in the genes implicated in Bedaquiline, Clofazimine, Linezolid and Delamanid resistance
| Drug | Gene | Other potential resistance conferring mutations | Mutation type |
|---|---|---|---|
| Bedaquilin and Clofazimine | mmpL5 | p.Ile948Val, p.Gly131Arg, p.Thr352Pro | Missense variants |
| Rv0678 | p.Ala124Gly, p.Asp141Glu, p.Thr161Asn, | Missense variants | |
| Rv1979c | p.Ala128Ser, p.Pro349Ala | Missense variants | |
| pepQ | p.Ala224Ser, p.Leu300Arg, p.Leu362Trp, | Missense variants | |
| Linezolid | rplC | p.Gly153Glu p.Ala155Asp, p.Thr156Pro | Missense variant |
| Delamanid | fgd1 | p.Ser38Arg, p.Thr92Pro, p.Phe102Cys, p.Gly199Ala, p.Glu213Asp | Missense variants |
| fbiC | p.Cys59Gly, p.Asp375Ala, p.Glu376Gly, p.Trp405Gly, p.Ile406Ser, p.Asp492Tyr, p.Glu503Gly, p.Ile638Ser, p.Leu672Val,p.Leu672Arg, p.Asp673Ala, p.Pro686Ala, p.Glu692Ala, | Missense variants | |
| p.Glu152* | Nonsense mutation | ||
| fbiA | p.Val73Gly, p.Met319Arg | Missense variants | |
| fbiB | p.Ile18Val, p.Ser54Ala, p.Ala104Glu, p.Leu249Arg, p.Glu250Ala, p.Ser262Ala, p.Val263Gly, | Missense variants | |
| ddn | p.Glu35Lys, p.Glu35Gly, p.Asp108Glu | Missense variants | |
| Rv2983 | p.His159Pro | Missense variant |