Table 2.
New studies in the field of IEXs therapeutic application
| Study name | source | year | ref |
|---|---|---|---|
| Anti-CTLA-4 antibody-functionalized dendritic cell-derived exosomes targeting tumor-draining lymph nodes for effective induction of antitumor T-cell responses | DC | 2020 | [119] |
| Exosome-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1 | DC | 2020 | [120] |
| Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo | DC | 2020 | [121] |
| M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment | M1 macrophage | 2020 | [122] |
| M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation | M2 macrophage | 2020 | [123] |
| Neutrophil-derived exosome from systemic sclerosis inhibits the proliferation and migration of endothelial cells | Neutrophil | 2020 | [124] |
| miR103a-3p in exosomes derived from human mast cells (MCs) following aggregation of FcεRI enhances IL-5 production from IL-33-stimulated type2 innate lymphoid cells (ILC2) via silencing protein arginine methyltransferase (PRMT) | Mast cells | 2020 | [125] |
| Eosinophil-Derived Exosomes Contribute to Asthma Remodeling by Activating Structural Lung Cells | Eosinophil | 2018 | [126] |
| NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice | NK cell | 2020 | [127] |
| Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes | NK cell | 2020 | [128] |
| Role of Chronic Lymphocytic Leukemia (CLL)-Derived Exosomes in Tumor Progression and Survival | B cell | 2020 | [129] |
| Exosomes derived from regulatory T cells ameliorate acute myocardial infarction by promoting macrophage M2 polarization | Treg | 2020 | [130] |
| CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity | CAR-T | 2019 | [131] |
DC Dendritic cell, CAR-T cell Chimeric antigen receptor expressing T cell, Treg Regulatory T cell