Table 1.
List of GPI-anchored proteins with q < 0.1 that are differential between CSF from Control individuals and ALS patients. N, neurons; O, oligodendroglial lineage; A, astrocytes; E, endothelial cells; MG, microglia. Cell specific expression profiles were derived from searches of brainrnaseq.org and proteinatlas.org
| Protein name | Gene symbol | P value | q-value | Z-score (ALS/control) | Cell Type |
|---|---|---|---|---|---|
| Acetylcholinesterase | ACHE | 0.0040 | 0.0535 | − 0.451 | N, O |
| Thy-1 membrane glycoprotein (Fragment) | THY1 | 0.0037 | 0.0537 | − 0.533 | N, O, E |
| Semaphorin-7A | SEMA7A | 0.0030 | 0.0573 | − 0.674 | N, O, MG |
| Repulsive guidance molecule A | RGMA | 0.0088 | 0.0576 | − 0.547 | N, A |
| Netrin-G1 | NTNG1 | 0.0033 | 0.0580 | − 0.566 | N, O |
| Carbonic anhydrase 4 | CA4 | 0.0069 | 0.0596 | − 0.532 | N, MG, E |
| RGM domain family member B | RGMB | 0.0046 | 0.0597 | − 0.569 | N, O, A, E |
| Neuronal growth regulator 1 | NEGR1 | 0.0023 | 0.0605 | − 0.565 | N, O, A, E |
| Ephrin-A3 | EFNA3 | 0.0149 | 0.0618 | − 0.571 | N |
| Reticulon-4 receptor (Fragment) | RTN4R | 0.0089 | 0.0625 | − 0.593 | N, A |
| Limbic system-associated membrane protein (Fragment) | LSAMP | 0.0103 | 0.0715 | − 0.390 | N, O, A |
| Contactin-1 | CNTN1 | 0.0014 | 0.0735 | − 0.337 | N, O, A |
| Cadherin-13 | CDH13 | 0.0317 | 0.0736 | − 0.569 | N, O |
| Oligodendrocyte-myelin glycoprotein | OMG | 0.0021 | 0.0750 | − 0.663 | N, O, A |
| Contactin-4 | CNTN4 | 0.0064 | 0.0760 | − 0.401 | N, O |
| Low affinity immunoglobulin gamma Fc region receptor III-B | FCGR3B | 0.0514 | 0.0771 | − 0.922 | MG |
| Ciliary neurotrophic factor receptor subunit alpha | CNTFR | 0.0082 | 0.0773 | − 0.377 | A |
| Reticulon-4 receptor-like 1 | RTN4RL1 | 0.0245 | 0.0816 | − 0.509 | N |
| Brevican core protein | BCAN | 0.0178 | 0.0845 | − 0.460 | A, O |
| Reticulon-4 receptor-like 2 | RTN4RL2 | 0.0006 | 0.0860 | − 0.677 | N, O |
| Opioid-binding protein/cell adhesion molecule | OPCML | 0.0278 | 0.0877 | − 0.419 | N, O, E |
| Glypican-1 | GPC1 | 0.0151 | 0.0904 | − 0.355 | N, A |
| Neuritin | NRN1 | 0.0419 | 0.0923 | − 0.465 | N, O, E |
| Contactin-3 | CNTN3 | 0.0197 | 0.0941 | − 0.379 | N, O |
| Ephrin-A5 | EFNA5 | 0.0459 | 0.0967 | − 0.463 | N, A |
| GDNF family receptor alpha-2 | GFRA2 | 0.0432 | 0.0969 | − 0.527 | N |
| GPI-anchored high density lipoprotein-binding protein 1 | GPIHBP1 | 0.0905 | 0.0974 | − 0.996 | O, E |
| Contactin-6 | CNTN6 | 0.0317 | 0.0981 | − 0.376 | N, O |
| Neural cell adhesion molecule 1 | NCAM1 | 0.0160 | 0.0991 | − 0.319 | N, O, A |