Figure 3.

Analysis of signaling pathways regulating MD3 expression. (A) Western blot images of screening for cytokines having an upregulating effect on MD3 in HT-29/B6 cells. (B) Densitometric analysis of MD3 expression in HT-29/B6 under the influence of IL-13 and different inhibitors. Among the tested inhibitors, STAT3 and STAT6 inhibition led to loss of the effect of IL-13 on MD3 expression (control = condition without any inhibitor pretreatment, * p < 0.05; ** p < 0.01; *** p < 0.0001 tested against the respective IL-13-free condition; # p < 0.05; ### p < 0.001 tested against IL-13 treatment; n = 3–5). (C) Representative Western blot images.