Table 1.

Results from studies by Çavuşoğlu et al. comparing the effects of oxytocin in CLP sepsis.

	Normal Group	Sham operated Group	CLP Group	CLP and saline Group	CLP and 0.4mg/kg oxytocin Group
Loss of brush border	0.1 ± 0.1	0.1 ± 0.1	2.8 ± 0.1**	2.6 ± 0.2**	1.6 ± 0.2#
Tubular dilation	0	0.3 ± 0.3	2.6 ± 0.3**	2.8 ± 0.1**	1.8 ± 0.3#
Mononuclear histological index (MNHI)	0.1 ± 0.1	0.6 ± 0.2*	2.5 ± 0.5**	2.8 ± 0.1**	1.1 ± 0.1##
Erythrocyte extravasation	0	0.1 ± 0.1	0.8 ± 0.1*	1.1 ± 0.1*	1.0 ± 0.2
Cast Formation	0	0.1± 0.1	0.6 ± 0.2*	0.8 ± 0.1*	1.1 ± 0.1

Results were represented as mean ± SEM. *p < 0.05, **p < 0.00001, different from normal and sham-operated groups; ^#p < 0.05, ^##p < 0.001, different from CLP and CLP + saline group. Comparison is done based on the levels of Plasma TNF- ∝, MDA, CRP, WBC and Creatinine levels. Results demonstrated that loss of brush border in proximal tubule cells around the glomerular structure, dilatation of proximal and distal tubules and MNHI were significantly less in CLP+ Oxytocin treated group; while cast formation in tubules, change in glomerular structure and erythrocyte extravasation were similar when compared to CLP and CLP+ saline group (220).

Table is from Suleyman Demirel University Journal of Health Science permissible to reuse under a CC-BY 4.0 license (open access).