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. 2022 Apr 29;13:797312. doi: 10.3389/fimmu.2022.797312

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Copyright © 2022 Zhao, Lyu, Zhai, Sun and Ding

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of metformin on gut microbiota in septic rats. (A–D) 16S rRNA analysis showed that the alpha diversity of gut microbiota such as Ace, Chao1, Shannon and Simpson index was slightly reduced in the CLP group compared to the C group. However, metformin treatment slightly reversed the alpha diversity reduction caused by sepsis. (E) The beta diversity of gut microbiota showed that the compositions in the CLP group were different from the C group. However, the composition of the gut microbiota in the MET group was similar to the C group. a P<0.05 (n = 5/group).