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. 2022 Apr 29;13:797312. doi: 10.3389/fimmu.2022.797312

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Copyright © 2022 Zhao, Lyu, Zhai, Sun and Ding

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The beneficial effect of metformin on gut microbiota in septic rats. (A–C) The gut microbiota at Phylum, Family, and Genus levels showed the difference among the C, CLP, and MET groups. (D–I) The specific gut microbiota abundance varied among the groups, such as the relative abundance of Alloprevotella, Escherichia_Shigella, Prevotella_9 and Muribaculaceae were decreased in the CLP group compared to the C group, but increased in the MET group compared to the CLP group rats; while ratio of Firmicutes/Bacteroidetes and Lactobacillus were increased in the CLP group compared to the C group, and decreased in the MET group.*: CLP vs C group; & MET vs CLP group. & P<0.05; **, && P<0.01; *** , &&& P<0.001; ns, not significant (n = 5/group).