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. Author manuscript; available in PMC: 2022 May 13.
Published in final edited form as: Sci Transl Med. 2022 Apr 27;14(642):eabm5527. doi: 10.1126/scitranslmed.abm5527

Fig. 3. Selective tau ablation in excitatory neurons prevents overactivation of the PI3K-AKT-mTOR pathway and megalencephaly in DS mice.

Fig. 3.

(A) Representative Western blot showing amounts of p-AKT, total AKT, p-S6 (Ser 240/244), and total S6 in the hippocampus of 2-month-old mice. MW markers are indicated in the middle. (B and C) p-AKT/total AKT (B) and p-S6/total S6 (C) ratios in the hippocampus of 2-month-old mice determined by Western blot analysis. Mean ratios in Control mice were defined as 1.0. (D) Brain weights of mice at 2 months of age. n = 14–36 mice per group. *P < 0.05 and **P < 0.01 by one-way ANOVA and Holm-Sidak test. Gray circles represent data from individual mice. Bars are means ± SEM.