Table 2.
Comparison of analyzed parameters in the group of women with PCOS divided according to the value of HOMA-IR or BMI.
| Parameters | PCOS | p Value | |
|---|---|---|---|
| HOMA-IR < 2.0; n = 43 | HOMA-IR ≥ 2.0; n = 17 | ||
| SOD activity [U/L] | 5.2 (4.7; 6.3) | 4.7 (4.3; 5.5) | 0.046 |
| Zn [µg/L] | 858.7 (769.7; 942.8) | 818.3 (752.7; 920.7) | NS |
| Cu [µg/L] | 813.8 (724.1; 989.0) | 958.1 (832.1; 1077.2) | 0.012 |
| Cu/Zn ratio | 1.0 (0.9; 1.1) | 1.1 (1.0; 1.2) | 0.015 |
| LH [lU/L] | 5.8 (3.4; 9.1) | 8.6 (5.6; 12.5) | NS |
| FSH [lU/L] | 5.8 (5.0; 7.0) | 5.9 (5.2; 6.5) | NS |
| FT4 [ng/dL] | 1.2 (1.0; 1.3) | 1.2 (1.0; 1.3) | NS |
| TSH [mU/L] | 1.9 (1.4; 2.9) | 1.9 (1.3; 2.5) | NS |
| SHBG [nmol/L] | 70.0 (46.7; 86.6) | 43.1 (22.8; 59.0) | 0.004 |
| Total testosterone [ng/mL] | 0.4 (0.2; 0.4) | 0.5 (0.4; 0.6) | 0.016 |
| Free testosterone [pg/mL] | 1.6 (1.1; 2.4) | 2.3 (1.2; 3.3) | NS |
| Androstenedione [ng/mL] | 2.5 (1.7; 3.5) | 4.0 (2.6; 4.8) | 0.024 |
| 17-β-E2 [pg/mL] | 30.5 (21.5; 48.6) | 37.8 (30.2; 50.5) | NS |
| 17-OHP [nmol/L] | 1.7 (1.1; 1.9) | 2.1 (1.6; 2.4) | 0.037 |
| BMI < 25.0; n = 40 | BMI ≥ 25.0; n = 20 | ||
| SOD activity [U/L] | 5.6 (4.3; 6.5) | 5.1 (4.5; 5.3) | NS |
| Zn [µg/L] | 867.6 (802.9; 942.8) | 834.2 (733.1; 959.1) | NS |
| Cu [µg/L] | 859.2 (742.6; 1003.9) | 852.3 (772.2; 1042.1) | NS |
| Cu/Zn ratio | 1.0 (0.9; 1.1) | 1.0 (0.9; 1.3) | NS |
| LH [lU/L] | 5.9 (22.2; 50.4) | 7.8 (3.4; 13.0) | NS |
| FSH [lU/L] | 6.4 (5.0; 7.1) | 6.1 (5.1; 6.6) | NS |
| FT4 [ng/dL] | 1.2 (1.1; 1.4) | 1.1 (1.0; 1.2) | NS |
| TSH [mU/L] | 1.8 (1.5; 2.5) | 1.7 (1.2; 2.5) | NS |
| SHBG [nmol/L] | 76.3 (52.7; 93.4) | 26.7 (17.1; 44.5) | 0.001 |
| Total testosterone [ng/mL] | 0.3 (0.2; 0.4) | 0.5 (0.4; 0.7) | 0.001 |
| Free testosterone [pg/mL] | 1.6 (1.0; 2.2) | 2.5 (1.3; 3.7) | 0.005 |
| Androstenedione [ng/mL] | 2.6 (1.7; 3.5) | 4.0 (1.8; 4.9) | 0.038 |
| 17-β-E2 [pg/mL] | 34.4 (22.2; 50.4) | 36.6 (28.6; 51.8) | NS |
| 17-OHP [nmol/L] | 1.6 (1.0; 2.0) | 2.3 (1.6; 2.5) | 0.030 |
Legend: Values shown as median (1st quartile, 3rd quartile); PCOS—polycystic ovary syndrome; SOD—superoxide dismutase; Zn—zinc; Cu—copper; LH—luteinizing hormone; FSH—follicle-stimulating hormone; FT4—free thyroxine; TSH—thyrotropin; SHBG—sex hormone-binding globulin; 17-β-E2—17-β-estradiol; 17-OHP—17-α-hydroxyprogesterone; NS—not significant.