Table 2.
Regulators of α7 nAChR expression.
| Effect | Agent | Action | Ref. |
|---|---|---|---|
| Downregulation of α7 nAChR | miR-98-5p | Negatively regulates the expression of α7 nAChRs | [80] |
| Upregulation of α7 nAChR | SIRT1 | Activates the Erk1/2 signaling pathway | [57] |
| Galantamine | Activates JNK signaling | [52] | |
| SP600125 | Inhibits JNK signaling | [42] | |
| SB202190 | Inhibits p38 MAPK signaling | [42] | |
| Morin | Restores decreased α7 nAChR mRNA expression | [84] | |
| RIC-3 | Promotes functional assembly of α7 nAChRs | [85,86] | |
| NACHO | Promotes functional assembly of α7 nAChRs | [87,88] | |
| Ly6h | Promotes functional assembly of α7 nAChRs | [89] |
Erk, extracellular signal-regulated kinase, JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; nAChR, nicotinic acetylcholine receptor; RIC-3, resistance to inhibitors of cholinesterase-3; SIRT1, Sirtuin 1.