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. 2022 Apr 29;14(9):2219. doi: 10.3390/cancers14092219

Figure 2.

Figure 2

Different parameters of PSA Kinetics. PSA kinetics represents useful tool during the history of prostate cancer from diagnosis to treatment of mCRPC allowing to monitor the follow-up or the efficacy of treatment. Baseline PSA is required at diagnosis and at the beginning of each new treatment. PSA response rate is the eventual decline > 50% in pre-treatment PSA following treatment. PSA response rate at 12 weeks is evaluated in different percentages. The PSA nadir is the lowest value reached during a treatment, another useful indicator is represented by the time in which PSA nadir was reached expressed in months. One of the parameters most commonly used in clinical practice is determination of the dynamics of PSA levels, expressed by PSADT and PSA velocity. These are routinely used in early setting but could be useful also in advanced setting. Abbreviation: PSA, prostate specific antigen; PSA DT, PSA doubling time; mCRPC, metastatic castration resistant prostate cancer.