FIGURE 2.

Circ_0011298 knockdown sensitized Taxol‐resistant NSCLC cells to Taxol. A and B, Circ_0011298 and TINAGL1 mRNA levels were detected in Taxol‐resistant NSCLC cells introduced with sh‐NC, sh‐circ_0011298#1, or sh‐circ_0011298#2. C‐P, Taxol‐resistant NSCLC cells were introduced with sh‐NC or sh‐circ_0011298#1. C and D, MTT assay was used to measure cell viability. (E) DNA synthesis was determined by EdU analysis. F‐H, Flow cytometry analysis was performed to analyze cell cycle process and apoptosis. I and J, Transwell assay was performed to detect cell migratory and invasive abilities (×100). K, IC50 of Taxol was assessed using MTT assay. L‐N, Glucose uptake, lactate consumption, and cellular ATP/ADP ratio were assessed using corresponding kits. O and P, Western blot was conducted to analyze Ki67, Bax, and MRP1 protein levels. *p < 0.05