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. 2022 Apr 8;36(5):e24408. doi: 10.1002/jcla.24408

FIGURE 5.

FIGURE 5

MiR‐486‐3p directly interacted with CRABP2. A, The predicted binding sites between CRABP2 and miR‐486‐3p were presented. B and C, The relationship between CRABP2 and miR‐486‐3p was verified by dual‐luciferase reporter assay. D and E, GEPIA database showed CRABP2 expression in tumor and normal tissue samples, and the survival rate for patients with high and low CRABP2 expression. F, CRABP2 mRNA expression was determined in normal, Taxol‐sensitive NSCLC, and Taxol‐resistant NSCLC tissues. G and H, The correlation between CRABP2 and miR‐486‐3p or circ_0011298 in Taxol‐resistant NSCLC tissues was analyzed. I and J, CRABP2 protein expression was examined in normal tissues, Taxol‐sensitive NSCLC tissues, Taxol‐resistant NSCLC tissues, Taxol‐resistant NSCLC cells, and parental cells. K, The protein expression of CRABP2 was examined in Taxol‐resistant NSCLC cells after transfection with miR‐NC/miR‐486‐3p. L and M, CRABP2 protein expression was measured in Taxol‐resistant NSCLC cells after introduction with sh‐NC, sh‐circ_0011298#1, sh‐circ_0011298#1+anti‐NC, or sh‐circ_0011298#1+anti‐miR‐486‐3p. *p < 0.05