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. 2019 Aug 7;18(3):732–745. doi: 10.5114/aoms.2019.87205

Figure 4.

Figure 4

NRG1 is a target gene of miR-124-3p and circ-RHOJ.1 serves as a sponge for miR-124-3p. A – Myocardial cells were co-transfected with psi-CHECK2 or luciferase plasmids containing the wild-type or mutated NRG1 3’-UTR or NC and miR-124-3p, NC inhibitor, or miR-124-3p inhibitor for 24 h. The relative luciferase intensities were measured with dual luciferase reporter assay, ***p < 0.001. B – Myocardial cells were co-transfected with psi-CHECK2 or luciferase plasmids containing the circ-RHOJ.1 and pcDNA or negative control (NC) and miR-124-3p, for 24 h. Dual luciferase reporter assay was carried out to verify the interaction between circ-RHOJ.1 and miR-124-3p, *p < 0.05; ***p < 0.001 versus mimics NC + pcDNA group; &p < 0.05 versus mimics + pcDNA group. All the data were presented as mean ± SD (n = 3)